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"But microdosing has not been well studied in clinical trials, and most of the data is anecdotal." She said that when someone asks her about microdosing a GLP-1, she advises that, since it's off-label (meaning not approved by the FDA), carefully monitoring their blood sugar, weight, and symptoms is essential

GI symptoms: Nausea, bloating, constipation, or fatigue are common

This data, combined with traditional biomarkers (HbA1c, BMI, cardiovascular risk markers) and provider clinical judgment, can help you and your healthcare team make a more informed decision about compounded versus branded semaglutide and build a stronger case for coverage